In clinical studies, after taking Excedrin Migraine, patients with moderate to severe migraines experienced effective migraine relief with just one dose, lasting relief, and major improvements in their ability to take part in normal activities. See your doctor for diagnosis of migraines and migraine relief options. The No. 1 Neurologist recommended OTC treatment for migraines (Among OTC medicine for migraines. Symphony Health Solutions, 2016.) Relieves migraine pain starting in just 30 minutes Relieves pain, sensitivity to light and sound, even nausea